The Estrous Cycle (n = 5 Mice Per Group) Measured during a Period of 6 wk
A, Representative estrous cycle in TR4+/+ (upper) and TR4−/− (lower) mice (E, estrus; D, diestrus; P, proestrus); B, percentage of days spent in each estrous cycle in TR4+/+ and TR4−/− mice; C, comparison of vaginal opening in TR4+/+ and TR4−/− female mice at 5+ wk old; D, age of first ovulation in TR4+/+ and TR4−/−mice.