Figure 1.

Log R ratio and B allele frequency plots for large copy number deletions (indicated in the graphs by a depression in the black line) on chromosomes 1 and 3 in samples F13 and F01, respectively.

A decrease in intensity, measured by log R ratio, is seen coupled with a loss of heterozygosity, measured by B-allele frequency. Notice how these aberrations can affect a single area (F01, right) or multiple areas (F13, left) on a chromosome. Chromosomal centromere is depicted by the ‘C’.