Figure 6.

Prepuce hyperplasia in the female GTs of the gain-of-function mutants of β-catenin. A, In the female GT with activated β-catenin in the mesenchyme, the prepuce exhibits hyperplasia. The histological sections corresponding to the levels of the distal GT represent preputial development to be accelerated in the constitutive active β-catenin mutants (arrows). B, Well-developed external genitalia observed in the gain-of-function β-catenin mutant female mice in comparison with those of the control female and male mice. Note that scrotal/perineal regions were not affected, showing the specificity of the resultant phenotypes. The dotted line indicates the scrotum.