Table 2.

Impact of Hypophysectomy on Gene Expression

Impact of Hypox	Change in Expression in
	M-Hypox Onlya	F-Hypox Onlya	M-Hypox and F-Hypoxa
Male-specific genes
Decrease (class I)	164	1	70
Increase (class II)	2	120	26
Other	0	0	17b
Female-specific genes
Decrease (class I)	0	137	59
Increase (class II)	58	1	20
Other	0	0	14c
Sex-independent genes
Increase	346	240	302
Decrease	289	233	395

Liver-expressed genes of interest (Table 1) were grouped based on their response to hypophysectomy in both males and females, and secondarily, based on whether gene expression was increased or decreased. The designation of class I and class II genes is as described in the text and in Table 3. Not tabulated are data for 1763 other genes of interest, namely, 189 male-specific genes, 154 female-specific genes, and 1313 sex-independent genes, the expression of which was not significantly changed after hypophysectomy (also see Table 3). A majority of these unchanged sex-specific genes actually lost sex specificity after hypophysectomy (i.e. male-female difference <2-fold), but the changes in gene expression did not reach the specified criteria of more than 2.0-fold and P < 0.005. 

^aAll numbers shown are gene counts. 

^bMale-specific genes down-regulated in Hypox males and up-regulated in Hypox females. 

^cFemale-specific genes down-regulated in Hypox females and up-regulated in Hypox males.