Table 4.

Impact of a Single or Two GH Injections Given to Hypox Male Rats on GH-Responsive Class I (panel A) and Class II (panel B) Sex-Specific Genes

A. Class I Genes	Up-Regulation by GH	All Class I Genes		Class IA		Class IB		Class IC
		Gene Count	%	Gene Count	%	Gene Count	%	Gene Count	%
Class I Male genes (251)	After first injection	26	53	13	41	12	92	1	25
	After second injection only	23	47	19	59	1	8	3	75
	Total:	49		32		13		4
Class I Female genes (210)	After first injection	24	65	8	44	14	88	2	67
	After second injection only	13	35	10	56	2	13	1	33
	Total:	37		18		16		3

B. Class II Genes	Down-Regulation by GH	All Class II Genes		Class IIA		Class IIB
		Gene Count	%	Gene Count	%	Gene Count	%
Class II male genes (146)	After fist injection	33	61	24	65	9	53
	After second injection only	21	39	13	35	8	47
	Total:	54		37		17
Class II female genes (78)	After first injection	5	26	2	15	3	50
	After second injection only	14	74	11	85	3	50
	Total:	19		13		6

Classes and subclasses of sex-specific genes are as defined in Table 3. Shown are class I genes induced by either one or two GH injections and class II genes suppressed by either one or two GH injections. “After first injection” designates genes that are up-regulated or down-regulated after both the first and the second GH injections. “After second injection only” designates genes that responded to the second GH injection but not to the first GH injection. Total number of genes in each class is shown in parentheses at left.