Table 1.
Microarray Analysis of Gene Expression Patterns in Undifferentiated Granulosa Cells Stimulated by FSH and PKA-CQR
| Accession No. | Name | FSHa | PKA-CQRb | Maximal Expressionc |
|---|---|---|---|---|
| FSH > PKA-CQR | ||||
| NM_017085 | P450arom | 260 | 58.0 | 4,680 |
| NM_012978 | LH/CG receptor | 7.5 | 2.1 | 131 |
| NM_017128 | Inhibin-βA | 5.6 | 1.4 | 3,631 |
| NM_019232 | SGK | 12.4 | 3.0 | 13,812 |
| FSH ∼ PKA-CQR | ||||
| NM_017286 | P450scc | 2,186 | 2,131 | 25,870 |
| NM_017265 | 3β-HSD | 172 | 135 | 29,220 |
| NM_031558 | StAR | 35.6 | 27.7 | 7,997 |
| NM_012590 | α-Inhibin | 6.8 | 6.3 | 34,059 |
| PKA-CQR > FSH | ||||
| NM_017123 | Amphiregulin | 3.9 | 8.4 | 2,706 |
| NM_017031 | Phosphodiesterase 4B | 6.7 | 16.4 | 424 |
| NM_030991 | Snap 25 | 10.6 | 30.4 | 532 |
| NM_019291 | Carbonic anhydrase-2 | 2.8 | 10.4 | 1,504 |
a
Fold increase by FSH stimulation. Data are the means of Illumina expression units from cells stimulated by FSH divided by the means of Illumina expression units of control incubations for each transcript (n = 3 per group).
b
Fold increase by PKA-CQR stimulation. Data are the means of Illumina expression units from cells stimulated by PKA-CQR divided by the means of Illumina expression units of control incubations for each transcript (n = 3 per group).
c
Data present the mean value (n = 3) of the maximum Illumina expression units from cells stimulated by either FSH or PKA-CQR. This reflects the abundance of each transcript.