Table 2. Genetic differences between Alkhurma hemorrhagic fever virus coding sequences of human (strain 1176 AF331718) and tick (strain JE7, DQ154114) origin*.
| Gene | No. mutated sites/no. sites in gene (%) |
Ka:Ks | |
|---|---|---|---|
| Synonymous mutations | Nonsynonymous mutations | ||
| VirC | 2/291 (0.69) | – | – |
| CTHD | – | 1/60 (1.67) | – |
| prM | 2/267 (0.75) | – | – |
| M | 4/225 (1.78) | 1/225 (0.45) | 0.20 |
| E | 6/1,488 (0.41) | 2/1488 (0.13) | 0.25 |
| NS1 | 4/1,062 (0.32) | 3/1,062 (0.28) | 0.43 |
| NS2a | 8/687 (1.16) | 1/687 (0.15) | 0.11 |
| NS2b | 2/393 (0.51) | 3/393 (0.76) | 0.60 |
| NS3 | 9/1,863 (0.48) | 5/1,863 (0.27) | 0.36 |
| NS4a | 2/378 (0.53) | 2/378 (0.53) | 0.50 |
| 2K | 1/69 (1.45) | – | – |
| NS4b | 4/756 (0.53) | 4/756 (0.53) | 0.50 |
| NS5 | 10/2,709 (0.37) | 3/2,709 (0.15) | 0.11 |
*Ka:Ks, ratio of nonsynonymous-to-synonymous nucleotides; VirC; mature virion C protein; CTHD, C-terminal hydrophobic domain; prM, premembrane; M, membrane; E, envelope; NS, nonstructural; 2K, transmembrane domain.