Table 2. Antiapoptotic therapeutic approaches for prevention of lymphocyte apoptosis in murine models of sepsis.

Strategy	Intervention	Reference
Prevent triggering of extrinsic pathway	Blockade of Fas ligand by using Fas fusion protein	(27)
Prevent triggering of extrinsic pathway	Prevent Fas expression by using siRNA	(28)
Prevent initiation	Anti-CD40 agonist antibodies	(29)
Prevent initiation	Treatment with Bcl-2 agonist peptides	(30)
Prevent triggering of intrinsic pathway	Antiretroviral protease inhibitors	(31)
Prevent execution phase	Anticaspase-8 siRNA	(28)
Prevent execution phase	Treatment with caspase inhibitors	(32,33)