Figure 3.

Systemic anisomycin-induced consolidation deficits are initially larger in magnitude and more persistent (to at least 14 d) compared to reconsolidation deficits. (A) During the last 3 min of the reversal fear conditioning session (CTX+), the consolidation group showed similar levels of freezing to the 3-min retrieval session in the reconsolidation group. Immediately and 2 h after this reversal day mice received either anisomycin or vehicle treatment. (B) When tested 1 d later, the vehicle-treated mice from the reconsolidation and consolidation groups showed equivalent levels of freezing. Mice treated with anisomycin after initial memory acquisition or retrieval showed freezing deficits compared to their vehicle controls. This deficit was larger in those mice treated after retrieval than it was in the mice treated after acquisition. (C) The anisomycin-induced deficit only persisted in the consolidation group; freezing recovered to vehicle levels in the reconsolidation group during the 14-d test.