Figure 8.

Summary of major experimental findings with memory deficits on test days expressed as the difference between vehicle and anisomycin treated animals within reconsolidation (R) and consolidation (C) groups. In experiment 1 a robust consolidation deficit was seen, whereas no reconsolidation deficit was observed. When the memory retrieval and pre-exposure sessions were shortened to 3 min, a reliable consolidation and reconsolidation deficit was produced by systemic anisomycin treatment (experiment 2). The consolidation deficit was initially larger than the reconsolidation deficit (1-d test) and persisted to 14 d, while the reconsolidation deficit did not (14-d test). Following intrahippocampal injections in experiment 5, the sizes of the reconsolidation and consolidation deficits were matched statistically (1-d test). Only the consolidation deficit persisted to the 14-d test. Removing the confound of repeated testing yielded an even less persistent reconsolidation deficit (open bars). In experiments 2 and 5, the consolidation deficit remains flat from the first to the second tests, whereas the reconsolidation deficit decreases in size across tests.