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FGF19 and FGF19dCTD signaling in adipose tissue. (A) Adipose tissue was excised from ob/ob mice (four animals per group) treated with 10 mg/kg BSA (BSA), FGF19, or FGF19dCTD (at 0.1, 1, or 10 mg/kg) 15 min after injection. Tissue lysates were prepared and pooled for Western blot analysis using phosphorylated ERK1/2 (pERK) or total ERK1/2 (T-ERK) antibodies. (B) Differentiated 3T3-L1 adipocytes were incubated for 72 h with recombinant FGF19 or FGF19dCTD and assayed for glucose uptake.
