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. 2009 Jul 13;3:117–125. doi: 10.2147/btt.2009.2872

Table 2.

Production and processing of rAHF-PFM

Fermentation technology Continuous chemostat perfusion
Cell culture medium Protein-free medium
Purification
  • Immunoaffinity chromatography Monoclonal antibodies expressed in plasma/albumin-free conditions

  • Cation exchange chromatography

  • Anion exchange chromatography

Viral inactivation Solvent/detergent treatment
Stabilizer Trehalose
Bulking agent Mannitol