Table 2.
Characteristics for the granulotoxicity, monocytotoxicity, and lymphotoxicity for all schedules considered. We present arithmetic mean and standard deviation (in parentheses) for logarithmized MCC and AOC adjusted for initial cell counts. Both low MCC and high AOC indicate high toxicity as well. Grey areas indicate the schedules with corresponding lowest toxicity for both filgrastim and pegfilgrastim as well
| G-CSF schedule | Without | Pegfilgrastim
|
Filgrastim
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 × 40 μg
|
4 × 10 μg
|
2 × 20 μg
|
|||||||||
| Day 0 | Day 1 | Day 2 | Day 0 | Day 1 | Day 2 | Day 0 | Day 1 | Day 2 | |||
| Granulocytes | MCC (log ml−1) | 13.0 (0.35) | 13.4 (0.59) | 13.5 (0.30) | 13.5 (0.52) | 13.1 (0.22) | 13.7 (0.44) | 13.1 (0.08) | 12.8 (0.33) | 13.2 (0.21) | 13.2 (0.52) |
| AOC (h) | 131.0 (36.7) | 48.0 (28.4) | 46.4 (19.9) | 46.8 (19.7) | 79.5 (26.6) | 39.6 (15.4) | 44.6 (2.7) | 111.6 (36.0) | 108.7 (22.8) | 90.2 (17.1) | |
| Monocytes | MCC (log ml−1) | 11.1 (0.42) | 11.6 (0.37) | 11.7 (0.30) | 11.6 (0.20) | 11.5 (0.22) | 11.9 (0.26) | 11.4 (0.11) | 11.1 (0.37) | 11.5 (0.23) | 11.6 (0.30) |
| AOC (h) | 158.8 (36.1) | 90.5 (42.1) | 81.1 (19.3) | 83.7 (20.0) | 135.5 (21.5) | 98.4 (15.5) | 99.9 (13.7) | 129.4 (35.6) | 125.0 (31.3) | 142.3 (26.4) | |
| Lymphocytes | MCC (log ml−1) | 14.6 (0.43) | 14.5 (0.40) | 14.4 (0.32) | 14.6 (0.19) | 14.0 (0.44) | 14.8 (0.15) | 14.7 (0.21) | 14.3 (0.34) | 14.5 (0.25) | 14.2 (1.1) |
| AOC (h) | 172.9 (59.2) | 162.9 (71.3) | 164.8 (20.4) | 146.8 (34.0) | 217.0 (53.3) | 169.6 (28.6) | 182.6 (30.3) | 202.2 (24.8) | 205.2 (25.9) | 203.5 (39.3) | |