Table 3.

Effectiveness of adalimumab for psoriasis

Reference	Study design	Study population n % females; age range baseline severity	Prior antipsoriatic treatment	Concurrent treatment	Results (effectiveness)
Papoutsaki 200762	Prospective open-label uncontrolled study to assess the effectiveness of adalimumab 40 mg/week in patients with plaque psoriasis not responding to all other biologics approved	n = 30 33% 30–75 years mean PASI 16.4	other biologics and conventional treatments approved for psoriasis	No other systemic treatments allowed. No information on concurrent topical therapy	Week 12 PASI 50/75/90: 90%/87%/70% Week 24 PASI 50/75/90: 83%/83%/77% Psoriatic arthritis (n = 19) Mean HAQ week 0 vs week 24: 1.0 vs 0.2
Heiberg 200863	Prospective register-based study to assess the comparative effectiveness of anti-TNFα therapy for PsA1	n = 150 patients receiving 172 treatment courses 37% mean 46 years	73% of patients were anti-TNFα therapy naïve	68% had concomitant MTX therapy	Drug withdrawal rates at 1 year: Adalimumab 14.3% Etanercept 24% Infliximab 25%
Van 200864	Retrospective chart review to assess the long-term effectiveness of adalimumab 40mg/week in moderate-to-severe plaque psoriasis	n = 49 n.r. n.r. n.r.	76% had prior treatment with other anti-TNFα agents	n.r.	Proportion of patients “clear/almost clear”: After 3 months of treatment: 88% Sustained effectiveness after 12 months: 78%

Notes: One study also included patients with rheumatoid arthritis and ankylosing spondylitis which are not the scope of this paper; n.r., not reported.