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Pharmacology of conventional IFN and two pegylated IFN preparations
| Conventional IFN | 12 kD PegIFN | 40 kD PegIFN | |
|---|---|---|---|
| Volume of distribution (L) | 25–30 | 20–40 | 8 |
| Half-life (h) | 3–8 | 54 | 65 |
| Time to serum peak (h) | 7–12 | 20 | 80 |
| Clearing | Renal | Renal | Hepatic and renal |
