Table 1.
The effect of G proteins on the doubling time of cells
Doubling time, hours | ||
Cell type | Low density | High density |
Wild-type | 13.0 ± 0.6 | 35.4 ± 4.3 |
aprA- | 9.7 ± 0.1** | 20.7 ± 0.4* |
cfaD- | 10.9 ± 0.4* | 17.7 ± 0.1** |
gα2- | 13.9 ± 0.1 | 34.9 ± 3.3 |
gα5- | 12.2 ± 0.5 | 34.6 ± 1.3 |
gα7- | 12.2 ± 0.9 | 28.6 ± 5.4 |
gα8- | 10.9 ± 0.3* | 13.4 ± 0.2** |
gα9- | 10.1 ± 0.3** | 18.3 ± 1.5** |
gβ- | 11.1 ± 0.4* | 24.1 ± 3.0 |
Doubling times were calculated using the data from Figure 2. Low density doubling times were calculated for cells in the range of 2 × 105 to 5 × 106 cells/ml. High density doubling times were calculated for cells in the range of 5 × 106 to 2 × 107 cells/ml. All values are means ± SEM's from three or more independent assays. A * indicates a statistically significant difference with p < 0.05; ** indicates p < 0.01, comparing the value to the wild type value (1-way ANOVA, Dunnett's test).