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. 2009 Aug 1;10:77. doi: 10.1186/1471-2199-10-77

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Copyright © 2009 Wu et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Time-dependent reduction in the levels of serum bilirubin and rHO-1 by siRNA in neonatal hyperbilirubinemia rats models. A and B: The inhibitory rate of siRNA-4 on HO-1 protein 48 hours after injection was 33%, after 72 hours, it was in a time-dependent decrease. No inhibitory effect of siRNA on HO-1 protein was found in NC group. C. Effect of 10 OD/20 g bw siRNA-4 on levels of bilirubin at different time points. *P < 0.05, compared with blank group; #P < 0.05, compared with NC group. Data represent the results from one of three independent experiments. Each group contained 4–6 mice.