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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Leukemia. 2009 Apr 9;23(8):1455–1461. doi: 10.1038/leu.2009.73

Table 1. The C3a-C3aR axis enhances adhesion of BM-derived Sca-1+ cells to BM stroma.

The number of CFU-GM from Sca-1+ cells from WT mice that adhered to WT strom a stimulated for 30 m in by C3a was arbitrarily assumed to be 100% in 1 hour and 3 hour adhesion assays. Data are pooled from quadruplicate samples from three independent experiments (n=12).

Source of Sca-1+
cells
[adhesion time]
Non-stimulated Stimulated by C3a
(1μg/ml, 30 min)
Stimulated by desArgC3a
(1μg/ml, 30 min)
WT [1 hr] 58+/-11* 100+/-21 67+/-15*
C3aR-/- [1 hr] 62+/-19* 64+/-17* 62+/-17*
WT [3 hrs] 49+/-11* 100+/-8 46+/-13*
C3aR-/- [3 hrs] 53+/-16* 49+/-20* 51+/-7*
*

p<0.00001

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