Doctor consultations for common childhood problems in early and late childhood according to maternal prenatal anxiety symptom scores
| OR (95% CI) for wheezing |
OR (95% CI) for earache |
OR (95% CI) for accident |
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|---|---|---|---|---|---|---|---|---|---|
| N (%) | Crude | Adjusted for sex | N (%) | Crude | Adjusted for sex | N (%) | Crude | Adjusted for sex | |
| Maternal anxiety at 18 wk | Symptoms between 6 and 18 mo | ||||||||
| 1st quartile (0-2) | 758/912 (83.1) | 1.0 (reference) | 1.0 (ref) | 924/988 (93.5) | 1.0 (reference) | 1.0 (reference) | 356/567 (62.8) | 1.0 (reference) | 1.0 (reference) |
| 2nd quartile (3-4) | 611/732 (83.5) | 1.03 (0.79-1.33) | 1.03 (0.79-1.34) | 733/807 (90.8) | 0.69 (0.48-0.97) | 0.69 (0.48-0.97) | 294/456 (64.5) | 1.08 (0.83-1.39) | 1.08 (0.83-1.40) |
| 3rd quartile (5-7) | 770/914 (84.2) | 1.09 (0.85-1.39) | 1.09 (0.85-1.40) | 903/978 (92.3) | 0.83 (0.59-1.18) | 0.83 (0.59-1.18) | 386/584 (66.1) | 1.16 (0.91-1.47) | 1.16 (0.91-1.47) |
| 4th quartile (8-16) | 735/848 (86.7) | 1.32 (1.02-1.72) | 1.33 (1.02-1.73) | 773/868 (89.1) | 0.56 (0.40-0.78) | 0.56 (0.40-0.78) | 354/490 (72.2) | 1.54 (1.19-2.0) | 1.55 (1.19-2.01) |
| P trend | .04 | .04 | .004 | .004 | .002 | .001 | |||
| Maternal anxiety at 18 wk | Symptoms between 69 and 81 mo | ||||||||
| 1st quartile (0-2) | 243/351 (69.2) | 1.0 (reference) | 1.0 (reference) | 739/1016 (72.7) | 1.0 (reference) | 1.0 (reference) | 318/444 (71.6) | 1.0 (reference) | 1.0 (reference) |
| 2nd quartile (3-4) | 205/314 (65.3) | 0.84 (0.60-1.16) | 0.83 (0.60-1.15) | 567/777 (73.0) | 1.01 (0.82-1.25) | 1.01 (0.82-1.25) | 208/317 (65.6) | 0.76 (0.55-1.03) | 0.75 (0.55-1.03) |
| 3rd quartile (5-7) | 246/383 (64.2) | 0.80 (0.59-1.09) | 0.78 (0.57-1.07) | 696/950 (73.3) | 1.03 (0.84-1.25) | 1.03 (0.82-1.25) | 271/416 (65.1) | 0.74 (0.55-0.99) | 0.74 (0.55-0.99) |
| 4th quartile (8-16) | 213/310 (68.7) | 0.98 (0.70-1.36) | 0.97 (0.70-1.35) | 527/689 (76.5) | 1.22 (0.97-1.53) | 1.22 (0.97-1.53) | 196/313 (62.6) | 0.66 (0.49-0.90) | 0.66 (0.49-0.90) |
| P trend | .74 | .69 | .12 | .12 | .009 | .009 | |||
| Maternal anxiety at 32 wk | Symptoms between 6 and 18 mo | ||||||||
| 1st quartile (0-2) | 658/793 (83.0) | 1.0 (reference) | 1.0 (reference) | 858/927 (92.6) | 1.0 (reference) | 1.0 (reference) | 325/526 (61.8) | 1.0 (reference) | 1.0 (reference) |
| 2nd quartile (3-4) | 624/749 (83.3) | 1.02 (0.78-1.34) | 1.03 (0.79-1.34) | 762/836 (91.1) | 0.83 (0.59-1.17) | 0.83 (0.59-1.16) | 333/497 (67.0) | 1.26 (0.97-1.62) | 1.26 (0.97-1.62) |
| 3rd quartile (5-7) | 812/971 (83.6) | 1.05 (0.81-1.35) | 1.05 (0.82-1.36) | 931/1021 91.2) | 0.83 (0.60-1.15) | 0.83 (0.60-1.15) | 376/579 (64.9) | 1.15 (0.90-1.46) | 1.15 (0.90-1.46) |
| 4th quartile (8-16) | 813/954 (85.2) | 1.18 (0.91-1.53) | 1.19 (0.92-1.54) | 864/960 (90) | 0.72 (0.52-1.0) | 0.72 (0.52-1.0) | 394/556 (70.8) | 1.50 (1.17-1.94) | 1.50 (1.17-1.94) |
| P trend | .20 | .19 | .06 | .06 | .006 | .006 | |||
| Maternal anxiety at 32 wk | Symptoms between 69 and 81 mo | ||||||||
| 1st quartile (0-2) | 213/313 (68.1) | 1.0 (reference) | 1.0 (reference) | 681/939 (72.5) | 1.0 (reference) | 1.0 (reference) | 286/405 (70.6) | 1.0 (reference) | 1.0 (reference) |
| 2nd quartile (3-4) | 209/322 (64.9) | 0.87 (0.62-1.21) | 0.86 (0.61-1.19) | 607/824 (73.7) | 1.06 (0.86-1.31) | 1.06 (0.86-1.31) | 247/366 (67.5) | 0.86 (0.64-1.17) | 0.86 (0.63-1.17) |
| 3rd quartile (5-7) | 260/400 (65.0) | 0.87 (0.64-1.19) | 0.85 (0.62-1.16) | 727/993 (73.2) | 1.04 (0.85-1.27) | 1.04 (0.85-1.27) | 275/409 (67.2) | 0.85 (0.63-1.15) | 0.85 (0.63-1.15) |
| 4th quartile (8-16) | 249/351 (70.9) | 1.15 (0.82-1.60) | 1.13 (0.81-1.58) | 583/762 (76.5) | 1.23 (0.99-1.54) | 1.23 (0.99-1.54) | 212/355 (59.7) | 0.62 (0.46-0.83) | 0.62 (0.46-0.83) |
| P trend | .43 | .48 | .10 | .10 | .003 | .003 | |||