Table III.
Relationship between maternal anxiety symptoms reported before (32 weeks of gestation) and after birth (8 months) and asthma in children age 7½ years
| OR (95% CI) for current asthma at 7½ y |
||||
|---|---|---|---|---|
| N asthma/no asthma (% with asthma) | Crude | Adjusted∗ | Adjusted for confounders∗ and for prenatal or postnatal anxiety | |
| Maternal anxiety at 32 wk gestation | ||||
| 1st quartile (0-2) | 156/1529 (9.3%) | 1 (reference) | 1 (reference) | 1 (reference) |
| 2nd quartile (3-4) | 166/1184 (12.3%) | 1.37 (1.09-1.73) | 1.33 (1.05-1.68) | 1.31 (1.03-1.67) |
| 3rd quartile (5-7) | 193/1251 (13.4%) | 1.51 (1.21-1.89) | 1.46 (1.16-1.83) | 1.42 (1.11-1.81) |
| 4th quartile (8-16) | 164/900 (15.4%) | 1.79 (1.41-2.26) | 1.68 (1.32-2.13) | 1.64 (1.25-2.17) |
| P (trend) | <.001 | <.001 | <.001 | |
| Maternal anxiety at 8 mo after birth | ||||
| 1st quartile (0-2) | 196/1668 (10.5%) | 1 (reference) | 1 (reference) | 1 (reference) |
| 2nd quartile (3-4) | 188/1427 (11.6%) | 1.12 (0.91-1.39) | 1.09 (0.88-1.35) | 0.99 (0.80-1.24) |
| 3rd quartile (5-7) | 138/795 (14.8%) | 1.48 (1.17-1.87) | 1.40 (1.10-1.77) | 1.18 (0.92-1.53) |
| 4th quartile (8-16) | 157/974 (13.9%) | 1.37 (1.10-1.72) | 1.26 (1.00-1.59) | 0.99 (0.76-1.29) |
| P (trend) | <.001 | .01 | .7 | |
∗
Adjusted for sex, preterm delivery, multiple birth, number of siblings, maternal age, maternal education, maternal history of asthma and allergy, prenatal tobacco smoke exposure, and problems during pregnancy (diabetes, hypertension, steroid intake).