FIG. 4.
Time course of ClS/F of METH from GD8 to GD20 in pregnant Sprague-Dawley rats after chronic infusion of 5.6 (top panel), 10 (middle panel), or 13.2 (bottom panel) mg/kg/day METH. ClS/F values were calculated based on serum METH concentrations, infusion rates, and normalized body weight on each GD. F was assumed to be 1 in pregnant rats. This assumption was based on previous studies conducted in our laboratory, in which F was determined to be 1 in male rats dosed with 3 mg/kg sc bolus METH (Gentry et al., 2004). The symbols *, †, and ‡ indicates a significantly (p < 0.05) lower clearance value compared to clearances on GD8, GD10, or GD13, respectively. All data points are mean ± SD.