. 2009 Jun 22;111(1):64–71. doi: 10.1093/toxsci/kfp133

TABLE 1.

Concordance Between Oxidative Stress and Damage Measurements in Brain and WBC and Reported Tumor Incidence in Sprauge-Dawley Rats.

Correlations	R²
GSH/GSSG in brain vs. OH8dG level in brain	0.36
OH8dG level in brain vs. OH8dG level in WBC	0.90*
Oxidative DNA damage (fpg comet) in brain vs. oxidative DNA damage (fpg comet) in WBC	0.91*
Oxidative DNA damage (fpg comet) in WBC vs. ROS in plasma	0.98*
OH8dG level in brain vs. ROS in plasma	0.97*
Adjusted OH8dG level in brain^a vs. tumor incidence^b	0.92*
Adjusted oxidative DNA damage in brain (comet assay)^a vs. tumor incidence^b	0.93*
Adjusted OH8dG level in WBC^a vs. tumor incidence^b	0.82*
Adjusted oxidative DNA damage in WBC (comet assay)^a vs. tumor incidence^b	0.90*

Note. Data were analyzed by linear regression. *Statistically significant (p < 0.05, ANOVA).

Data were normalized with doses used in tumor incidence bioassay.

Tumor incidence data were from Quast and Friedman (2002).