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Rescue of wt Kir1.1 from inactivation by 500 nM external TPNQ. Oocytes were maintained in 1 mM [K] and inactivated by reducing internal pH from 8 to 6.3, using permeant acetate buffers. Kir1.1 remained inactivated during realkalization to pHi = 8, but could be reactivated by exposure to external TPNQ. The fraction of channels rescued from inactivation increased progressively with 5 min (cyan line), 10 min (orange line), and 20 min (magenta line) exposure to TPNQ.
