Fig. 6.

In vivo application of anti-miR-27b antagomir affects regeneration of injured muscle. (A) Immunohistochemistry of pectoralis muscle sections 6 days after cardiotoxin injury showing Pax7-positive satellite cells under the basal lamina of muscle fibers, outlined by laminin, with control or anti-miR-27b antagomirs. (B) As in A, using a Pax3 antibody to mark satellite cells. (C) Summary of the number of Pax3- or Pax7-positive cells per cross-section of a myofiber. (D) Average muscle fiber diameter in control and anti-miR-27b antagomir-treated regenerating muscle at 6 days.