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DFO decreases ROS generation, prevents methylglyoxal modification of p300, and increases VEGF expression in high glucose culture. HAECs were treated for 5 days in LG, HG, HG with DFO (HG/DFO), HG with DMOG (HG/DMOG), or HG with DFO and DMOG (HG/DFO/DMOG). The following evaluations were then performed: (A) ROS generation, (B) IP/WB of p300 modification by methylglyoxal (MG), and (C) VEGF mRNA expression. *, P < 0.05 vs. LG group. n = 3.
