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Measurement of intraocular pressure (IOP) demonstrated significant increases (P < 0.01) in rats that received episcleral injection with hypertonic saline solution (A). Hematoxylin/eosin staining of normal (B) and glaucomatous (C) retinas showed a significantly lower (P < 0.01) number of RGCs (arrows) in glaucomatous eyes (D).
