Fig. 1.
Diagrammatic comparison of BdmGC-1 and -1B. Both BdmGC-1 isoforms exhibit all of the characteristics of receptor GCs, including (from left to right) an extracellular domain (ECD; 82–443 of BdmGC-1 and 82–489 of BdmGC-1B), a transmembrane region (TM; 504–524 of BdmGC-1 and 550–570 of BdmGC-1B), a kinase-homology domain (KHD; 584–845 of BdmGC-1 and 630–891 of BdmGC-1B), and a cyclase catalytic region (CYC; 911-1097 of BdmGC-1 957-1143 of BdmGC-1B). An extra insertion (347–392) with 4 additional cysteines in the ECD and absence of a C-terminal sequence are distinctive characteristics of BdmGC-1B.