Table 1.

Phylogenetic prediction of sialic acid synthesis in bacteria

	Organism	NCBI class*	Host/environment	Disease	NulO known
a	S.agalactiae	4	Human	MG, SP, PN	Neu
	S. suis	4	Swine, human	MG, SP, endocarditis	Neu
	E. coli K1	3	Human, avian	MG, SP, GE, cystitis	Neu
	R. gnavus	4	Human	NK, gut symbiont	NK
	F. nucleatum	5	Human, animal	Periodontal diseases	NK
c	C. jejuni	1	Chicken, human	GE, autoimmunity	Neu
	N. meningitidis	2	Human	MG, SP	Neu
	B. cereus G9241	4	Soil, animal	Anthrax-like PN	NK
	H. acinonychis	1	Feline	Gastritis in cheetah	NK
	F. johnsoniae	3	Soil, aquatic	NK	NK
	F. psychrophilum	3	Aquatic, fish	Fry syndrome, fish	NK
	Algoriphagus sp. PR1	3	Aquatic	NK	NK
	Flavobacterium sp. MED217	3	Seawater	NK	NK
	I. ioihiensis	4	NK, hydrothermal vent	NK	NK

MG; meningitis. SP, septicemia. PN, pneumonia. GE, gastroenteritis. NK; none known. Here ″a″ and ″c″ refer to phylogenetic clades shown in Fig. 3A.

*NCBI classifications are as follows: 1, ε-Proteobacteria; 2, β-Proteobacteria; 3, Bacteroidetes; 4, Firmicutes; 5, Fusobacteria.