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Activities of LNA/DNA co-oligomer EGSs. (A) Induction of cleavage of 32P-labeled aac(6′)-Ib mRNA by LNA/DNA co-oligomers with different substitution configurations in the ACCA region and LNA2. (B) Induction of cleavage of 32P-labeled aac(6′)-Ib mRNA by EGSC3 (low case) and LNA/DNA co-oligomers with different substitution configurations in the AS region while leaving ACCA region constant.
