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. 2009 Jul 28;106(32):13230–13235. doi: 10.1073/pnas.0906529106

Fig. 4.

Fig. 4.

Internalization and in vivo effect of DNA/LNA co-oligomers. (A) Epiflourescence microscopy images of E. coli AS19 or E. coli wild-type and CLSM images of E. coli AS19 preincubated with Alexa488-labeled LNA10 for 30 min are shown at the indicated magnification. (B) Effect of Ak on the survival of E. coli AS19 (pFC9) cells preincubated with LNA9 (50 nM), LNA10 (5 μM), or LNA1 (5 μM). Results are expressed as log of mean± SD of colony forming units per milliliter (log CFU/mL). Experiments were performed by triplicate. Similar results were observed in 3 independent assays. *, P < 0.05.