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. 2009 Sep 4;5(9):e1000633. doi: 10.1371/journal.pgen.1000633

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Crickmore et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Wild type haltere. (B) vg-Gal4 UAS-Ubx halteres show haltere to wing transformations due to Ubx silencing. (C) vg-Gal4 UAS-Antp halteres fail to produce any haltere to wing transformations. (D) vg-Gal4 UAS-AbdA halteres show haltere to wing transformations that are indistinguishable from those seen with UAS-Ubx. AbdA and Ubx have very similar homeodomains and also share the UbdA motif in the C-terminus, consistent with these domains playing a critical role in silencing. (E) vg-Gal4 UAS-AUA (Antp N-terminus, Ubx homeodomain, Antp C-terminus) halteres show no transformation to wing in 8/10 samples and mild transformations in 2/10 samples. (F) vg-Gal4 UAS-AAU (Antp N-terminus, Antp homeodomain, Ubx C-terminus) halteres show no haltere to wing transformations. (G) vg-Gal4 UAS-UU* (Ubx N-terminus, Ubx homeodomain, deletion of the C-terminus) halteres show no haltere to wing transformations. (H) vg-Gal4 UAS-AUU (Antp N-terminus, Ubx homeodomain, Ubx C-terminus) halteres show haltere to wing transformations indistinguishable from those seen with UAS-Ubx.