Table 2.
Associations of PTEN SNPs with colon cancer n (%)
| SNP | Cases | Controls |
Base model1 |
Full model2 |
||||
| OR | 95% CI | P | OR | 95% CI | P | |||
| rs926091 | ||||||||
| CC | 289 (69.1) | 351 (72.8) | 1.0 | 1.0 | ||||
| CT | 122 (29.2) | 122 (25.3) | 1.18 | 0.87-1.60 | 0.61 | 1.12 | 0.79-1.60 | 0.73 |
| TT | 7 (1.7) | 9 (1.9) | 1.12 | 0.40-3.13 | 0.71 | 0.99 | 0.29-3.41 | 0.92 |
| rs2299939 | ||||||||
| CC | 270 (64.6) | 325 (67.4) | 1.0 | 1.0 | ||||
| CA | 134 (32.1) | 147 (30.5) | 1.15 | 0.85-1.55 | 0.56 | 1.01 | 0.72-1.42 | 0.18 |
| AA | 14 (3.3) | 10 (2.1) | 1.96 | 0.82-4.66 | 0.25 | 2.13 | 0.84-5.38 | 0.11 |
| rs2248293 | ||||||||
| TT | 181 (43.3) | 212 (44.0) | 1.0 | 1.0 | ||||
| TC | 196 (46.9) | 210 (43.6) | 1.04 | 0.78-1.39 | 0.21 | 1.04 | 0.47-1.45 | 0.52 |
| CC | 41 (9.8) | 60 (12.4) | 0.77 | 0.48-1.22 | 0.23 | 0.86 | 0.51-1.46 | 0.51 |
| rs12357281 | ||||||||
| GG | 353 (84.4) | 408 (84.7) | 1.0 | 1.0 | ||||
| GC/CC3 | 65 (15.6) | 74 (15.3) | 0.93 | 0.64-1.37 | 0.98 | 0.99 | 0.65-1.53 | 0.98 |
1
Base model adjusted for age, gender and race;
2
Full model further adjusted for BMI, family history of colorectal cancer, NSAID use, and physical activity based on 328 cases and 390 controls;
3
Only three cases and two controls were of genotype CC, so they were combined with the heterozygotes to ensure validity of model fit.