Table 1.
Effect of pre-treatment and post-treatment with DEX on the histopathological grade in 8 rabbits at 2 days after VNR infusion.
| Region | Loss of venous endothelial cells | p value | Inflammatory cell infiltration | p value | Edema | p value | Thrombus | p value | Epidermal degeneration | p value | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Grade | 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | ||||||
| Proximal | Control | 6 | 2 | 0 | 0 | 0 | 1 | 3 | 4 | 2 | 3 | 2 | 1 | 8 | 0 | 0 | 0 | 0 | 2 | 4 | 2 | |||||
| Pre-treatment with DEX | 8 | 0 | 0 | 0 | N.S. | 6 | 1 | 1 | 0 | <0.01 | 7 | 1 | 0 | 0 | <0.05 | 8 | 0 | 0 | 0 | N.S. | 0 | 7 | 1 | 0 | <0.05 | |
| Post-treatment with DEX | 8 | 0 | 0 | 0 | N.S. | 4 | 3 | 0 | 1 | <0.01 | 7 | 0 | 0 | 1 | N.S. | 8 | 0 | 0 | 0 | N.S. | 0 | 5 | 1 | 2 | N.S. | |
| Distal | Control | 8 | 0 | 0 | 0 | 1 | 2 | 3 | 2 | 1 | 2 | 2 | 3 | 8 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | |||||
| Pre-treatment with DEX | 6 | 2 | 0 | 0 | N.S. | 7 | 1 | 0 | 0 | <0.01 | 8 | 0 | 0 | 0 | <0.01 | 8 | 0 | 0 | 0 | N.S. | 0 | 8 | 0 | 0 | <0.05 | |
| Post-treatment with DEX | 8 | 0 | 0 | 0 | N.S. | 5 | 0 | 1 | 2 | N.S. | 6 | 0 | 2 | 0 | <0.05 | 8 | 0 | 0 | 0 | N.S. | 2 | 4 | 1 | 1 | N.S. | |
Numbers in the table represent the number of observations. P values show a significant difference from control. N.S.; not significant.