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Inverse relationship between proportion of non-viable (apoptotic) cells and antibody productivity in hybridoma cultures. 2 × 105 viable 4/C6 hybridoma cells/ml were seeded with different proportions of apoptotic cells (non-viable cells obtained from cultures at the end of plateau phase). Monoclonal antibody (IgG1) productivity was assessed in cell-free supernatants four days later. The inverse correlation was significant (p < 0.005)
