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. Author manuscript; available in PMC: 2009 Aug 13.
Published in final edited form as: J Cereb Blood Flow Metab. 2009 Mar 25;29(5):1022–1034. doi: 10.1038/jcbfm.2009.28

Figure 2.

Figure 2

The adverse effect of AMP on ischemic outcomes in rats. (A) Representative pictures of TTC-stained brain sections after a 2-h MCAO and 24-h reperfusion, showing a decreased infarct volume in icepack-induced hypothermia (Hypoth.) group compared with that in normothermia (Normoth.) group, and an increased infarct volume and hemorrhagic transformation (HT, arrows) in AMP-treated rats. (B) Brain hypothermia reduced infarct volume and AMP increased infarct volume induced by MCAO in rats. Data are presented as mean ± s.d., n = 8 to 10 per group, analyzed by ANOVA; **P < 0.01 between two groups. (C) AMP caused seizure and increased death rate after MCAO. Data are presented as rate and analyzed using χ2-test, **P < 0.01 versus vehicle (Veh.) group. (D) AMP increased rates of HT after a 2-h MCAO reperfusion in rats. Animal: percentage of animals with HT; section: percentage of sections with HT. Data are presented as rate and analyzed using χ2-test, **P < 0.01 versus vehicle group.