Table 2.
JunD modulates a broad array of cell types and clinical scenarios
| Cellular process | Treatment | Effect on JunD expression | Outcome | References |
|---|---|---|---|---|
| Human ovarian cell differentiation | LHRH and FSH/LH | JunD protein levels increase | JunD is upregulated during cell maturation to arrest the cells at G0 | Gunthert et al. (2002) |
| Human epithelial ovarian cancer | Disease | JunD mRNA levels decrease | Downregulation of junD may contribute to the malignant phenotype | Neyns et al. (1996) |
| Adult mouse hearts under chronic moderate pressure overload | Moderate thoracic aortic constriction | JunD protein levels decrease | JunD protects from cardiac hypertrophy, apoptosis, and angiogenesis under pressure overload | Hilfiker-Kleiner et al. (2005) |
| Failing human myocardium | Hearts obtained at the time of transplantation | junD mRNA levels decrease by factor of four | junD downregulation in myopathic heart | Pollack et al. (1997) |
| Chicken chondrocyte differentiation | Parathyroid hormone | JunD protein levels increase | JunD suppresses chondrocyte maturation | Kameda et al. (1997) |
| Mouse T-cell differentiation | Ubi-junDm junD−/− transgenic cells | Not applicable | JunD suppresses lymphocyte proliferation and has a negative effect on Th cell differentiation | Meixner et al. (2004) |
| Human myeloblastic leukemia | UV radiation and TPA | junD mRNA levels increase | UV upregulates junD in ML1 cells via PKC-coupled Erk-signaling pathway and plays a role in UV-induced cell death | Li et al. (2002b) |
| Splenic marginal zone lymphoma (SMZL) | Analysis of genome-wide gene expression | junD mRNA levels increase | junD as well as other AP-1 genes may to be autoregulated by a MAP kinase-independent mechanism in SMZL | Troen et al. (2004) |
| Human intestinal epithelial cells | Polyamine depletion | junD mRNA is stabilized | Polyamines downregulates junD mRNA post-transcriptionally | Li et al. (2002a) |
| Mouse embryonic fibroblasts | V-C or H2O2 | JunD protein level and transcriptional activity increase | JunD plays an antagonistic role to UV-induced and H2O2-induced apoptosis | Zhou et al. (2007) |
Abbreviations: FSH, follicle-stimulating hormone; LH, luteinizing hormone; LHRH, luteinizing hormone-releasing hormone; TPA, TPA, 12-O-tetradecanoyl-phorbol-13-acetate.