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. Author manuscript; available in PMC: 2009 Aug 13.
Published in final edited form as: J Neurochem. 2008 Aug 22;107(2):578–587. doi: 10.1111/j.1471-4159.2008.05645.x

Fig. 1.

Fig. 1

Leptin protects hippocampal CA1 neurons against ischemic injury in rats. (a) Representative microphotographs of hematoxylin-stained hippocampal CA1 regions at 72 h after global ischemia in rats. (a-i) sham-operated; (b-i) vehicle-treated ischemia; and (c-i) leptin-treated ischemia. (a-ii), (b-ii), and (c-ii) demonstrate the magnified CA1 neurons whose origins are indicated by the boxes in (a-i), (b-i), and (c-i), respectively. (b) Viable CA1 neurons were counted and presented as cell number per hippocampal section, and the mean numbers were plotted for each group. Sham: sham-operated; Veh.: vehicle-treated ischemia; Lep 2 μg, Lep 4 μg and Lep 6 μg: 2 μg, 4 μg and 6 μg leptin were administered at 20 min after ischemia, respectively. Data are mean ± SEM, assessed by anova and post hoc Scheffe's tests. **p < 0.01 vs. vehicle-treated ischemia group. *p < 0.05 vs. vehicle-treated ischemia group. Scale bars = 150 μm in (a-i), (b-i), and (c-i); 100 μm in (a-ii), (b-ii) and (c-ii).