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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Neurobiol Dis. 2009 Jan 3;34(2):199–211. doi: 10.1016/j.nbd.2008.12.011

Figure 1. shRNA-mediated Knockdown of Endogenous Mecp2 Reduced Dendritic Length in Pyramidal Hippocampal Neurons, without Affecting Axonal Morphology.

Figure 1

A. Representative examples of 4 div hippocampal neurons transfected with a shRNA control sequence (left) or shRNA interfering sequence to knockdown endogenous Mecp2 (right). Neurons were co-transfected with eGFP (green) to perform quantitative morphological analyses (scale bar = 10μm). B. Population data on axonal length and branch points. C. Population data on dendritic length and branch points. In this and all subsequent figures, * indicates p<0.05, ** indicates p<0.01, and *** indicates p<0.001, from unpaired Student's t test or one-way ANOVA (see text for details). Additionally, in this and all subsequent figures, arrowheads indicate the position of the axons.