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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Neurobiol Dis. 2009 Jan 3;34(2):199–211. doi: 10.1016/j.nbd.2008.12.011

Figure 6. Bdnf Overexpression Partially Rescued Dendritic Atrophy in Neurons Expressing RTT-Associated MECP2 Mutations, Increasing Dendrite Length Only to Control Levels.

Figure 6

A. Representative examples of neurons transfected with a control GFP plasmid, plasmids to overexpress to different missense MECP2 mutations (R106W or T158M) commonly found in Rett syndrome patients, and a plasmid to overexpress Bdnf (scale bar = 10μm). For quantitative morphological analyses, neurons were co-transfected with eGFP (green) or stained with anti-α-tubulin antibodies (blue). B. Population data on axonal length and branch points. C. Population data on dendritic length and branch points.