Table 1.
Baseline characteristics of incident diabetes cases and controls included in the trajectory analysis.
| Variable | Control | Incident diabetes | P |
|---|---|---|---|
| N | 6033 | 505 | |
| Age (yrs) | 52.6 ± 7.1 | 53.1 ± 6.6 | 0.12 |
| Male (%) | 71.1 | 66.3 | 0.029 |
| Caucasian (%) | 92.3 | 79.8 | <0.0001 |
| Body mass index (kg/m2) | 25.60 ± 3.63 | 28.18 ± 4.99 | <0.0001 |
| Fasting glucose (mmol/L) | 5.21 ± 0.47 | 5.71 ± 0.91 | <0.0001 |
| 2h postload glucose (mmol/L) | 5.38 ± 1.42 | 7.06 ± 2.48 | <0.0001 |
| Fasting insulin (pmol/L) | 47 ± 30 | 73 ± 30 | <0.0001 |
| 2h postload insulin (pmol/L) | 259 ± 222 | 473 ± 351 | <0.0001 |
| HOMA2-%S (%)* | 145.1 ± 63.2 | 103.4 ± 58.8 | <0.0001 |
| HOMA2-%B (%) # | 78.4 ± 30.3 | 88.5 ± 39.0 | <0.0001 |
Data are presented as Mean ± SD or %. Comparisons were done using 2-sample t-tests, or Fisher’s exact tests as appropriate. HOMA2-%S and HOMA2-%B were calculated using HOMA2 calculator v2.2 (Diabetes Trials Unit, University of Oxford, Oxford, UK).27,28
*
HOMA2-%S – homeostasis model assessment insulin sensitivity
#
HOMA2-%B - homeostasis model assessment beta cell function