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. Author manuscript; available in PMC: 2010 Sep 18.
Published in final edited form as: Neurosci Lett. 2009 Jun 17;461(2):85–89. doi: 10.1016/j.neulet.2009.06.004

Fig. 2. Inhibition of MeHg induced IL-6 release by PLA2inhibitors.

Fig. 2

Mouse glia were treated with various concentrations of AACOCF3 (Fig. 2A), MAFP (Fig. 2B) or BEL (Fig. 2C) two hours after plating. After overnight incubation, cells were treated with 5 μM MeHg (without inhibitors) overnight, and then the viability (open circles, left-side axis) and IL-6 levels in the medium (solid circles, right-side axis) were determined. IL-6 release caused by 5 μM MeHg was used as 100% in this set of analyses. Results indicated that all three PLA2 inhibitors decreased MeHg induced IL-6 release. Among them, BEL was the only one that could significantly prevent MeHg cytotoxicity.