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. Author manuscript; available in PMC: 2009 Aug 13.
Published in final edited form as: Biomark Med. 2009 Jun 1;3(3):275–288. doi: 10.2217/bmm.09.21

Table 1.

Gene Description Identified as an ovarian TVM by Transmembrane Extracellular
ADAM12 ADAM metallopeptidase domain 12 (meltrin a) [1] & [2] ✓ ✓
CSPG2 Chondroitin sulfate proteoglycan 2 (versican) [1] & [2] ✓
EGFL6 EGF-like domain, multiple 6 [1] & [2] ✓
FJX1 Four jointed box 1 (Drosophila) [1] & [2] ✓
FZD10 Frizzled homologue 10 (Drosophila) [1] & [2] ✓
MXRA5 Matrix-remodeling associated 5 [1] & [2] ✓
PLXDC1 (TEM7) Plexin domain containing 1 [1] & [2] ✓ ✓
TNFAIP6 Tumor necrosis factor, a-induced protein6 [1] & [2] ✓
TNFRSF21 Tumor necrosis factor receptor superfamily, member 21 [1] & [2] ✓
BDKRB2 bradykinin receptor B2 [1] ✓
C6orf69 potassium channel tetramerisation domain containing 20 [1] ✓
CD24 CD24 molecule [1] ✓
CLDN1 claudin 1 [1] ✓
COL11A1 collagen, type XI, alpha 1 [1] ✓
COL15A1 collagen, type XV, alpha 1 [1] ✓
COL22A1 collagen, type XXII, alpha 1 [1] ✓
DEFB1 defensin, beta 1 [1] ✓
DSG2 desmoglein 2 [1] ✓
EPB41L3 erythrocyte membrane protein band 4.1-like 3 [1] ✓
ESM1 endothelial cell-specific molecule 1 [1] ✓
F2RL1 coagulation factor II (thrombin) receptor- like 1 [1] ✓
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 [1] ✓
GPM6B glycoprotein M6B [1] ✓
GPR105 G protein-coupled receptor 105 [1] ✓
IGSF4 immunoglobulin superfamily, member 4 [1] ✓
KCNK5 potassium channel, subfamily K, member 5 [1] ✓
NID2 nidogen 2 (osteonidogen) [1] ✓ ✓
OlfML2B olfactomedin-like 2B [1] ✓ ✓
PCDH17 protocadherin 17 [1] ✓
SCNN1A sodium channel, nonvoltage-gated 1 alpha [1] ✓
SLAMF8 (BLAME) SLAM family member 8 [1] ✓
SLIT2 slit homolog 2 (Drosophila) [1] ✓ ✓
SPON1 spondin 1, extracellular matrix protein [1] ✓
STC2 stanniocalcin 2 [1] ✓
TACSTD1 tumor-associated calcium signal transducer 1 [1] ✓
THY1 Thy-1 cell surface antigen [1] ✓
CKLFSF8 Chemokine-like factor superfamily 8 [2] ✓ ✓
COL5A3 Collagen, type V, a3 [2] ✓
DKFZP586- H2123 Regeneration-associated muscle protease, transcript variant 2 [2] ✓
G1P2 IFNa-inducible protein (clone IFI-15K) [2] ✓
MMP9 Matrix metallopeptidase 9 (gelatinase B, 92- kDa type IV collagenase) [2] ✓
MUC1 Mucin 1, transmembrane, transcript variant 4 [2] ✓
POSTN Periostin, osteoblast- specific factor [2] ✓
SPP1 Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T- lymphocyte activation 1) [2] ✓
STC1 Stanniocalcin 1 [2] ✓
1

Buckanovich, R.J., D. Sasaroli, A. O’Brien-Jenkins, et al.: Tumor vascular proteins as biomarkers in ovarian cancer. J Clin Oncol 25, 852–61 (2007).

2

Lu, C., T. Bonome, Y. Li, et al.: Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma. Cancer Res 67, 1757–68 (2007).