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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Allergy. 2008 Sep;63(9):1156–1163. doi: 10.1111/j.1398-9995.2008.01709.x

Figure 3.

Figure 3

Selective decrease of circulating quantum of eosinophils by Siglec-F antibody administration in the HES/CEL model. HES/CEL is induced by transplanting lethally irradiated wild type mice with FIP1L1/PDGFR-transduced bone marrow cells derived from IL-5 transgenic mice. Once quantum of eosinophils started increasing above the IL-5 transgenic level, mice were treated with Siglec-F antibodies every 48 h, and the quantum of eosinophils in the peripheral blood was monitored (A). As the disease and number of eosinophils escalated, the dose of antibody was increased from 20 to 100 μg/mouse. Simultaneously, the total white blood cell count was monitored by Turk's staining as a control (B). Data are mean ± SD of eight mice/group. P-value is determined by two-tailed, equal variance t-test.