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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Allergy. 2008 Sep;63(9):1156–1163. doi: 10.1111/j.1398-9995.2008.01709.x

Figure 4.

Figure 4

Siglec-F antibody administration leads to eosinophil apoptosis in vivo. IL-5 transgenic mice were treated with Siglec-F antibody (mouse monoclonal, 20 μg/mouse). Eosinophil apoptosis in the peripheral blood was determined by flow cytometry 2 h following the administration of antibody. Apoptotic eosinophils (CCR3+ Annexin-V+ 7AAD- cells) were determined. Panel A shows a representative mouse from each group (isotype-matched control and Siglec-F antibody-treated) and panel B shows quantification from a representative experiment (one out of three experiments, each performed with 4–8 mice/group). P-value was determined by two-tailed, equal variance t-test.