Table 2.
Characteristics of Mor-evoked responses
| EC50 (μm) | nH | Emaxa | ||
|---|---|---|---|---|
| α3β2 wtb | 20 ± 2 | 3.1 ± 1.6 | 0.2 | (4; 2) |
| α3T115Cβ2 | 30 ± 2 | 1.4 ± 0.1 | 0.29 ± 0.01 | (6; 2) |
| α3β2T150C | 26 ± 1 | 2.3 ± 0.2 | 0.33 ± 0.04 | (5; 1) |
| α3β2S148C | 110 ± 40 | 1.4 ± 0.5 | 0.36 ± 0.05 | (3; 1) |
| α3β2S192C | 20 ± 6 | 1.8 ± 0.7 | 0.08 ± 0.01 | (5; 1) |
| α3β2T193C | 20 ± 3 | 1.7 ± 0.3 | 0.24 ± 0.1 | (11; 1) |
| α3A106Cβ2 | 62 ± 11 | 2.1 ± 0.7 | 0.56 ± 0.05 | (5; 1) |
| α3S161Cβ2 |
Values are means ± SEM. In the last column, the number of oocytes tested and the number of donors, respectively, are given in parentheses. wt, Wild type.
aEmax, the maximum response at saturating concentrations of Mor, was measured relative to the response elicited by ACh alone (as an internal control), using an [ACh] ∼ EC50 as indicated in Table 1.
bData from Wu et al. (2008).