Table 2.

Univariable risk of CMV Infection or Disease

Risk factor		N	Hazard ratio (95% CI)	P-value
Donor and recipient CMV status		555		<0.001
	CMV stats D-R-		Reference group
	CMV stats D+R+		11.3 (6.3, 20.2)
	CMV stats D+R-		9.2 (5.2, 16.2)
	CMV stats D-R+		5.1 (2.6, 9.9)
Transplant type		576		<0.001
	Heart and lung		Reference group
	Single lung		2.0 (0.84, 4.8)
	Bilateral cadaveric		1.2 (0.83, 1.8)
	Living Donor		3.8 (2.1, 6.9)
Age at transplant		575		0.027
	Age quintile 1 (0.0- 5.6 yrs)		Reference group
	Age quintile 2 (5.6-11.6 yrs)		1.9 (1.1, 3.4)
	Age quintile 3 (11.6-14.2 yrs)		2.0 (1.2, 3.5)
	Age quintile 4 (14.2-16.9 yrs)		2.0 (1.2, 3.5)
	Age quintile 5 (16.9-21 yrs)		2.5 (1.4, 4.4)
Era of transplant		577		0.85
	2002-2005		Reference group
	1985-1993		0.99 (0.59, 1.7)
	1993-1997		1.2 (0.75, 1.8)
	1997-1999		0.86 (0.51, 1.5)
	1999-2002		1.04 (0.67, 1.6)
Female gender		577	1.2 (0.85, 1.6)	0.34
Cystic Fibrosis etiology		576	1.3 (0.95, 1.7)	0.11
Donor CMV positive		563	5.2 (3.6, 7.5)	<0.001
Recipient CMV positive		567	2.1 (1.6, 2.8)	<0.001
Any induction treatment		533	1.4 (1.01, 1.9)	0.040
Home going regimen: cyclosporine		577	1.4 (0.95, 1.9)	0.089
A2 rejection prior to CMV		577	1.3 (0.98, 1.8)	0.070
Second rejection prior to CMV		577	1.5 (1.08, 2.0)	0.014
Second A2 rejection prior to CMV		577	1.9 (1.4, 2.8)	<0.001
PFI prior to CMV		577	1.00 (0.62, 1.6)	0.99
RVI prior to CMV		577	0.64 (0.31, 1.3)	0.22

CMV – cytomegalovirus, D – donor, R – recipient, PFI – pulmonary fungal infection, RVI – respiratory viral infection