Figure 5. Clustering of experiments in the Boshoff compendium using expression of the mycolic acid biosynthetic genes.

Clustering was performed with hierarchical clustering using pearson correlation for the distance metric and the average linkage method. Known mycolic acid inhibitors do not cluster based solely on gene expression. This is consistent with the clustering of all M. tb genes reported by [17]. Similarly, predicted inhibitors and enhancers do not form distinct clusters.