Table 2. Summary of E-Flux predicted mycolic acid enhancers from Boshoff data set.
Predicted Enhancers | |||
Chlorpromazine/GSNO | Non-specific | Weak* | New |
Rifapentine‡ | Non-specific | Weak | New |
Rifampicin‡ | Non-specific | Weak | New |
Chlofazimine/GSNO | Non-specific | Weak | New |
GSNO | Specific | Strong* | New |
Menadione/GSNO | Non-specific | Very weak* | New |
Triclosan | Non-specific | Very weak* | Incorrect? |
Results are shown for all significant predictions from the set of 437 experiments in Boshoff et al [17]. Strong effects are defined as effects showing greater than +/−3 log change between control and drug; weak enhancing effects have greater than +1 log change, and we list two very weak effects defined as prediction lying outside the 95% null confidence interval. Specific effects indicate effects on mycolic acid biosynthesis as contrasted to effects over a broad range of pathways – see text for more details.
Prediction made only for certain replicates.
Prediction made only for certain doses.
Conditions with both enhancing and inhibiting predictions among replicates were excluded.