Figure 3.
Medications in each category: Increase methadone: fluoxetine, fluvoxamine, paroxetine, sertraline, omeprazole, metronidazole, ketoconazole, diltiazem Decrease methadone: efavirenz, nevirapine, lopinavir+ritonavir, butalbital, ascorbic acid Altered metabolism: didanosine, zidovudine, amytriptyline, doxepin, nortriptyline, clomethiazole., promethazine, nifedpine Benzodiazepines: clonazepam, diazepam, lorazepam Other opioids: codeine, fentanyl, morphine, oxycodone Possible risk: atazanavir, azithromycin, levofloxacin, ofloxacin, quetiapine, risperidone, venlafaxine Conditional risk: amitriptyline, nortriptyline, paroxetine, sertraline, citalopram, doxepin, fluoxetine, ketoconazole