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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Neuropsychopharmacology. 2009 Jun 3;34(10):2296–2304. doi: 10.1038/npp.2009.57

Figure 4.

Figure 4

Toluene appeared to act directly at GABA nerve terminals, since an increase in miniature IPSC frequency was evident in the presence of tetrodotoxin used to block action potentials in the inhibitory interneurons. A, Consecutive five second long recordings of miniature IPSCs for control and in the presence of toluene. B, Rate meter plot showing the time course of toluene-induced increase in the frequency of IPSCs and recovery following washout of the abused inhalant. The GABA receptor antagonist, gabazine was applied at the end of this experiment to demonstrate that these synaptic currents were all GABA-dependent. C, Summary data from ten experiments showing that toluene produced a significant increase in IPSC frequency (mean ± SD, * - p < 0.05; ** - p < 0.001).